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KMID : 0370220030470030125
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Yakhak Hoeji
2003 Volume.47 No. 3 p.125 ~ p.129
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Topoisomerase I Inhibition of 2-Substituted 5-Nitrobenzimidazoles
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권민진
Edmond J. Lavoie/김정선/J. Lavoie E/Kim JS
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Abstract
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A stories of 2-phenyl-5-nitrobenzimidazoles substituted at the para positron of the 2- phenyl moiety was sinthesized & evaluated for their activity to inhibit topoisomerase I. The structure-activity relationship study revealed that neither the electronic nor lipophilic parameters were related to the topoisomerase I inhibition. A strict spatial requirement seems to be present for retention of topoisomerase I inhibition activity.
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KEYWORD
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